L-Histidine monohydrochloride monohydrate
L-Histidine monohydrochloride monohydrate
CAS: 5934-29-2
Molecular Formula: C6H12ClN3O3
L-Histidine monohydrochloride monohydrate - Names and Identifiers
| Name | L-Histidine monohydrochloride monohydrate |
| Synonyms | L-HIS HCL H2O H-His-OH*HCl*H2O L-HISTIDINE HCL H2O L-Histidine hcl Monohydrate L-histidine hydrochloride hydrate L-HISTIDINE MONOHYDROCHLORIDE H2O L-Histidine Hydrochloride Monohydrate L-HISTIDINE HYDROCHLORIDE MONOHYDRATE L-(+)-HISTIDINE HYDROCHLORIDE MONOHYDRATE L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE L-Histidine monohydrochloride monohydrate L-ALPHA-AMINO-BETA-(4-IMIDAZOLYL)PROPIONIC ACID MONOHYDROCHLORIDE L-ALPHA-AMINO-4(OR 5)-IMIDAZOLEPROPIONIC ACID MONOHYDROCHLORIDE, MONOHYDRATE |
| CAS | 5934-29-2 |
| EINECS | 611-821-4 |
| InChI | InChI=1/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1 |
| InChIKey | CMXXUDSWGMGYLZ-XRIGFGBMSA-N |
L-Histidine monohydrochloride monohydrate - Physico-chemical Properties
| Molecular Formula | C6H12ClN3O3 |
| Molar Mass | 209.63 |
| Density | 1.49 g/cm3 |
| Melting Point | 254°C (dec.)(lit.) |
| Boling Point | 458.9°C at 760 mmHg |
| Specific Rotation(α) | 9.9 º (c=11, 6 N HCl) |
| Flash Point | 231.3°C |
| Water Solubility | 169.9 g/L (20 ºC) |
| Solubility | Soluble in formic acid, soluble in water, insoluble in ethanol and ether |
| Vapor Presure | <1 hPa (20 °C) |
| Appearance | White crystal or crystalline powder |
| Color | White |
| Merck | 14,4720 |
| BRN | 4168261 |
| PH | 3.5-4.5 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| MDL | MFCD00151027 |
| Physical and Chemical Properties | White crystals or crystalline powders. Odorless. Slightly sour and bitter. About 250% (after drying) melted and decomposed. Stable in nature. The aqueous solution is acidic (pH 3.5~4.5). Soluble in water (39g/100ml,24 C), the solubility in water is much larger than L-histidine. Insoluble in ethanol and ether. Belongs to the quasi-essential amino acids (infant essential amino acids), synthesis in the human body is slow. Such as the lack can lead to developmental delay, easy to eczema and other symptoms. The physiological effects of D-type and L-type are the same. |
| Use | This product is for scientific research only and shall not be used for other purposes. |
L-Histidine monohydrochloride monohydrate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | MS3119000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29332990 |
L-Histidine monohydrochloride monohydrate - Nature
Open Data Verified Data
- This product is colorless crystal or white crystalline powder; Almost odorless, slightly salty taste; Acidic reaction in aqueous solution. Soluble in water, insoluble in ethanol, ether or chloroform. The melting point was 249-253 °c.
- L-histidine is a basic amino acid containing imidazole nucleus in the molecule, which is a semi-essential amino acid and is an essential amino acid for maintaining the growth and development of infants. L-histidine is synthesized by 5-Phosphoribosyl pyrophosphate and ATP in the organism, and it is the synthetic precursor of histamine, urinal diacid, Carnosine and other biological substances. It has anti-ulcer effect, inhibit gastric motility and gastric acid secretion; Can accelerate the production of red blood cells, white blood cells and iron intake in vivo.
Last Update：2024-01-02 23:10:35
L-Histidine monohydrochloride monohydrate - Preparation Method
Open Data Verified Data
- extraction method.
- fermentation method.
- injection preparation method
Last Update：2022-01-01 11:10:21
L-Histidine monohydrochloride monohydrate - Standard
Authoritative Data Verified Data
This product is (L)2-amino -3-(lH-imidazol-4-yl) propionic acid hydrochloride monohydrate. The content of C6H9N302 • HCl • H20 shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
L-Histidine monohydrochloride monohydrate - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless.
- This product is soluble in water, insoluble in ethanol or ether.
specific rotation
take this product, precision weighing, plus 6mol/L hydrochloric acid solution dissolved and quantitative dilution made in each lml containing about 0. The llg solution was measured according to the law (General rule 0621), and the specific rotation was from 8.5 ° to 10.5 °.
Last Update：2022-01-01 15:06:54
L-Histidine monohydrochloride monohydrate - Introduction
The precursor of histamine relies on the catalysis of histidine decarboxylase.
Last Update：2022-10-16 17:26:46
L-Histidine monohydrochloride monohydrate - Use
Open Data Verified Data
- amino acid drugs. For the adjuvant treatment of peptic ulcers. Also can treat anemia and angina, aortitis, cardiac insufficiency and other cardiovascular diseases.
- usage and dosage: 0. 6G orally, 3 times a day. Subcutaneous or intramuscular injection, daily 0.2g, for 3 to 4 weeks. Combined with calcium gluconate, can reduce the pain.
Last Update：2022-01-01 11:10:22
L-Histidine monohydrochloride monohydrate - Differential diagnosis
Authoritative Data Verified Data
- a solution containing about 0.4mg per 1 ml was prepared by adding appropriate amounts of this product and the reference substance histidine hydrochloride, dissolving and diluting with water, respectively, as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 372).
Last Update：2022-01-01 15:06:54
L-Histidine monohydrochloride monohydrate - Safety
Open Data Verified Data
The injection had headache, flushing and sensation of heat.
Last Update：2022-01-01 11:10:22
L-Histidine monohydrochloride monohydrate - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 3.5~4.5.
transmittance of solution
take l.Og of this product, add water 10ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), determine the transmittance at 430nm wavelength, not less than 98.0%.
chlorine content
take about 0.4g of this product, precision weighing, add 50ml of water to dissolve, add 2ml of dilute nitric acid, according to the potentiometric titration method (General rule 0701), with silver nitrate titration solution (0.lmol/L) titration. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 3.545mg of C1. The chlorine content shall be 16.7%-17.1% based on the dry product.
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 2.0 ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 2.0 ml of standard ammonium chloride solution, it shall not be deeper (0.02%).
other amino acids
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 50mg per lml as a test solution; Take 1ml for precision measurement and put it in a 500ml measuring flask, dilute to the scale with water, shake well, as a control solution; Take the appropriate amount of histidine hydrochloride control and proline control, and put them in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 2 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-glacial acetic acid-water (0.95:1:1) to develop, spread, dry, spray with ninhydrin in acetone solution (1-50), heat at 80°C until spots appear, and immediately inspect. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. The test solution should show impurity spots, and its color should be compared with the main spot of the control solution, not deeper (0.2%).
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Iron Salt
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy metals
take this product 2. 0g, add water 23ml dissolved, add acetate buffer (p H 3. 5) 0821, inspection according to law (general principles the first law), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take an appropriate amount of this product, add endotoxin test water to dissolve, with 0.1 mol/L sodium hydroxide solution to adjust the pH value to 7.0, according to the law to check (General 1143), each lg of histidine hydrochloride containing endotoxin should be less than 6.0EU. (For injection)
Last Update：2022-01-01 15:06:55
L-Histidine monohydrochloride monohydrate - Content determination
Authoritative Data Verified Data
take about 0.2g of this product, precision weighing, add 5ml of water to dissolve, add 1 ml of formaldehyde solution and 20ml of ethanol neutral mixed solution (phenolphthalein indicates neutral), add a few drops of phenolphthalein indicator solution, with sodium hydroxide titration solution (0.lmol/L) titration. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 10.48mg of C6H9N302. HC1. H20.
Last Update：2022-01-01 15:06:56
L-Histidine monohydrochloride monohydrate - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 15:06:56
L-Histidine monohydrochloride monohydrate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:06:56
L-Histidine monohydrochloride monohydrate - Reference Information
| pH range of acid-base indicator discoloration | 3 - 4 at 105g/l at 25°C |
| LogP | -3.32 at 25℃ |
| biological activity | L-Histidine monohydrochloride monohydrate (L-Histidine hydrochloride hydrate, H-His-OH.HCl.H2O) is a structural analog of the essential amino acid L-histidine, it is a reversible inhibitor of protein biosynthesis and can cause different responses of non-tumorigenic cells and tumorigenic cells in culture. |
| Use | nutritional supplement. Slow synthesis in the human body, the essential amino acids. Can be used to strengthen infant food, food for patients after surgery. When making bread with chemical leavening agents, the addition of histidine, leucine, arginine can improve the flavor. biochemical reagents, medical raw materials. A precursor of histamine, catalysed by histidine decarboxylase |
| production method | by-products in the separation of lysine from defatted soybean hydrolysate. Among the basic amino acids, they are the least basic and can be separated from other basic amino acids by ion exchange resin column. Alternatively, it may be separated by forming a poorly soluble mercury salt, 3, 5-dichlorobenzenesulfonate, or the like. Obtained from the hydrolysis of hemoglobin with hydrochloric acid. Prepared by fermentation. |
Last Update：2024-04-09 21:54:55
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View History
L-Histidine monohydrochloride monohydrate
4-叔丁基-2-氯苯乙酮
2-METHYLCYCLOPROPANECARBOXYLIC ACID
4-CHLOROBENZYLSULFONYLACETIC ACID
Potassium hydrogen 4-sulphonatobenzoate
2,2-二羟基-4-甲氧基苯甲酮
2-propylpiperidin-4-one HCl
CLODRONIC ACID
5-甲基磺酰基-3氰基吡啶
2,5-DIBROMO-3-NITRO-4-PICOLINE
4-叔丁基-2-氯苯乙酮
2-METHYLCYCLOPROPANECARBOXYLIC ACID
4-CHLOROBENZYLSULFONYLACETIC ACID
Potassium hydrogen 4-sulphonatobenzoate
2,2-二羟基-4-甲氧基苯甲酮
2-propylpiperidin-4-one HCl
CLODRONIC ACID
5-甲基磺酰基-3氰基吡啶
2,5-DIBROMO-3-NITRO-4-PICOLINE